Latent Space

Latent Space

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The podcast & newsletter where 170,000+ AI Engineers gather to talk models, tools and ideas. Breaking news today you will use at work tomorrow! Full show notes and newsletter at https://latent.space

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AI Security After Codex and Claude Code — Zico Kolter & Matt Fredrikson, Gray Swan
1:07:31
Latent Space Latent Space

AI Security After Codex and Claude Code — Zico Kolter & Matt Fredrikson, Gray Swan

Gray Swan co-founders Zico Kolter and Matt Fredrikson explain why AI systems require a fundamentally different security approach than traditional software, highlighting how their automated red teaming system 'Shade' has begun to outperform human experts at finding model vulnerabilities. They emphasize the urgent need to treat AI agents as inherently untrusted entities capable of correlated failures across the software ecosystem.

2 days ago · 8 points
The AI Frontier: from FLOPs to Megawatts — Anjney Midha, AMP
1:00:37
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The AI Frontier: from FLOPs to Megawatts — Anjney Midha, AMP

Anjney Midha argues that AI infrastructure is facing a crisis of inefficiency and cultural misalignment, proposing that compute be treated as a utility through an Independent System Operator model that pools multi-cloud resources while embedding community incentives directly into unit economics.

6 days ago · 10 points
🔬 The Limits of AI in Science - Why We Need Self-Driving Labs — Joseph Krause, Radical AI
1:16:50
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🔬 The Limits of AI in Science - Why We Need Self-Driving Labs — Joseph Krause, Radical AI

Joseph Krause explains why AI alone cannot discover new industrial materials—unlike biology, alloys cannot be represented as simple strings and require physical ground truth across synthesis, microstructure, and processing. Radical AI is building self-driving labs to close the loop between AI hypothesis generation and automated experimentation, aiming to compress the 15-30 year materials development timeline.

7 days ago · 7 points
🔬 The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
1:10:12
Latent Space Latent Space

🔬 The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

Alex Rives demonstrates how the 'bitter lesson' of AI scaling applies to protein biology, showing that massive transformer models trained on billions of evolutionary sequences develop emergent world models capable of predicting structure, function, and designing novel antibodies without prior biological knowledge.

28 days ago · 9 points