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Long-form interviews and conversations with tech, AI, and finance leaders (30min+)
The Trump administration is moving to repeal the 2009 "endangerment finding," the legal foundation for all federal climate regulations, following a years-long covert campaign by conservative lawyers who secured funding and drafted the executive orders now being implemented.
The post-WWII global order was designed to contain the USSR through a security-for-trade bargain, but it became structurally obsolete after the Cold War ended; now, irreversible demographic decline is collapsing the economic foundations of globalism, with Trump merely officiating the inevitable break rather than causing it.
Mike Novogratz joins Anthony Pompliano at Bitcoin Investor Week to discuss why veteran macro investors face their toughest decade ahead, why Bitcoin has consolidated after its $100k milestone exhaustion, and how AI-driven productivity may allow the Fed to keep rates low despite a fraying dollar reserve system.
OpenAI's head of engineering Sherwin Wu reveals that AI now writes nearly all code at OpenAI, transforming engineers from line-by-line coders into 'sorcerers' managing fleets of agents, while warning that current AI capabilities represent the worst these models will ever be as we approach an era of one-person billion-dollar startups.
Romantic attachment repurposes childhood bonding neural circuits involving autonomic regulation, empathy, and positive delusions, where healthy relationships require the capacity for mutual physiological soothing without codependency, while failed autonomic matching predicts relationship dissolution.
The January jobs report reveals an economy artificially propped up by healthcare hiring while masking broader weakness, as new AI tools trigger market panic over imminent white-collar automation.
Nachiket Mor argues that India's healthcare crisis stems not from funding shortages—India already spends enough to achieve universal coverage—but from fundamental design failures that combine archaic public sector models with outdated private insurance concepts, creating fragmented, passive care that rewards hospitalization over health.
Steinberger details his evolution to an 'agentic engineering' workflow using multiple CLI-based AI agents simultaneously, arguing that mastery requires developing empathy for how agents perceive limited context while embracing imperfection and concise prompts over complex orchestration.
Ben Thompson argues that AI companies should adopt Meta-style user profiling for advertising rather than contextual chat-based ads, which creates conflicts of interest and limits inventory; he also discusses Taiwan's urban convenience and how aggregators like Booking.com capture more value than suppliers.
BlackRock is buying a specific crypto token for the first time ever, while Bitcoin sits at $67k with traders preparing for high volatility around tomorrow's CPI inflation data release.
Peter Steinberger discusses OpenClaw, an open-source AI agent that exploded to over 175,000 GitHub stars by connecting messaging apps to autonomous system-level actions, featuring emergent capabilities like unprompted audio processing and self-modifying architecture that signals a fundamental shift from coding to agentic engineering.
AlphaFold2's 2020 breakthrough solved single-chain protein structure prediction using evolutionary sequence correlations, but the field still struggles with folding dynamics, protein complexes, and molecules lacking evolutionary data, while expanding to small molecules and nucleic acids.